TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms

TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms

Unresolved inflammation is a significant predictor for developing chronic pain, and targeting the mechanisms underlying inflammation offers opportunities for therapeutic intervention. During inflammation, matrix metalloproteinase (MMP) activity contributes to tissue remodeling and inflammatory signa...

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Bibliographic Details
Main Authors: Brittany E. Knight, Nathan Kozlowski, Joshua Havelin, Tamara King, Stephen J. Crocker, Erin E. Young, Kyle M. Baumbauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
pain
thermal hyperalgesia
mechanical hypersensitivity
ongoing pain
matrix metalloproteinase
conditioned place preference
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00220/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00220/full

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