The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-ter...

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Bibliographic Details
Main Authors: Tian-Li Duan, Guang-Jun He, Li-Dan Hu, Yong-Bin Yan
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
DNA damage response
function switch
intrinsically disordered domain
nucleolar localization
phosphorylation
poly(A)-specific ribonuclease (PARN)
RNA maturation
structure switch
Online Access:https://www.mdpi.com/2073-4409/8/8/836

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https://www.mdpi.com/2073-4409/8/8/836

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