MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription
<p>Translocations between the human Mixed Lineage Leukemia (MLL) and AF4 Family (AFF) member genes, are implicated in leukemia. Mutations to AFFs can disrupt lymphopoesis, CNS development and spermatogenesis. However, despite the growing list of pathologies linked to AFF members, their evoluti...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2007-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v03p0225.htm |