Stochastic transcription in the p53‐mediated response to DNA damage is modulated by burst frequency

Abstract Discontinuous transcription has been described for different mammalian cell lines and numerous promoters. However, our knowledge of how the activity of individual promoters is adjusted by dynamic signaling inputs from transcription factors is limited. To address this question, we characteri...

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Bibliographic Details
Main Authors: Dhana Friedrich, Laura Friedel, Ana Finzel, Andreas Herrmann, Stephan Preibisch, Alexander Loewer
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20199068