Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2

Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2

Background/Aims: Renal tubular epithelial cells and fibroblasts are the main sources of myofibroblasts, and these cells produce the extracellular matrix during tubulointerstitial fibrosis (TIF). Histone deacetylases (HDAC) inhibitors exert an antifibrogenic effect in the skin, liver and lung. Sirtui...

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Bibliographic Details
Main Authors: Fang-Fang He, Ren-Yu You, Chen Ye, Chun-Tao Lei, Hui Tang, Hua Su, Chun Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sirtuin 2
Fibroblast activation
Tubulointerstitial fibrosis
Murine double-minute 2
Online Access:https://www.karger.com/Article/FullText/488613

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https://www.karger.com/Article/FullText/488613

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