A phase II study of high-dose celecoxib and metronomic 'low-dose' cyclophosphamide and methotrexate in patients with relapsed and refractory lymphoma

BACKGROUND AND OBJECTIVES: Relapsed, histologically aggressive non-Hodgkin lymphoma (NHL) has a poor prognosis; relapsed patients who do not respond to second line therapy or are unfit for BMT have a worse prognosis. Angiogenesis is increased in aggressive NHL and could be targeted by selective cycl...

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Bibliographic Details
Main Authors: Naser Abd El Bary, Tarek Hashem, Hasan Metwally, Ashraf Abd Ghany, Hager Abd El Mageed
Format: Article
Language:English
Published: Elsevier 2010-01-01
Series:Hematology/Oncology and Stem Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1658387610500517