Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.

Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes, particularly on innate immunity genes whose products mediate the direct interaction between the host...

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Bibliographic Details
Main Authors: Luis B Barreiro, Meriem Ben-Ali, Hélène Quach, Guillaume Laval, Etienne Patin, Joseph K Pickrell, Christiane Bouchier, Magali Tichit, Olivier Neyrolles, Brigitte Gicquel, Judith R Kidd, Kenneth K Kidd, Alexandre Alcaïs, Josiane Ragimbeau, Sandra Pellegrini, Laurent Abel, Jean-Laurent Casanova, Lluís Quintana-Murci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2702086?pdf=render

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http://europepmc.org/articles/PMC2702086?pdf=render

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