Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth

Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth

Nogo-A, a glycoprotein expressed in oligodendrocytes and central nervous system myelin, inhibits regeneration after injury. Antibodies against Nogo-A neutralize this inhibitory activity, improve locomotor recovery in spinal cord-injured adult mammals, and promote regrowth/sprouting/saving of damaged...

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Bibliographic Details
Main Authors: Vini Nagaraj, Thomas Theis, Anmol Singh Johal, Arihant Seth, Jada Gore, Neha Arsha, Mukti Patel, Helen Baixia Hao, Nikki Kurian, Melitta Schachner
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Nogo-A
antibody
neurite outgrowth
cell culture
mouse
signal transduction
Online Access:https://www.mdpi.com/1422-0067/21/15/5417

Internet

https://www.mdpi.com/1422-0067/21/15/5417

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