An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model

An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) such as PD-1/PD-L1 inhibitors has been well established for various types of cancer. Monotherapy with ICIs, however, can achieve a durable response in only a subset of patients. There is a great unmet need for the ICI-resistant-tumors. S...

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Bibliographic Details
Main Authors: Koichi Kitagawa, Maho Tatsumi, Mako Kato, Shota Komai, Hazuki Doi, Yoshiko Hashii, Takane Katayama, Masato Fujisawa, Toshiro Shirakawa
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
cancer vaccine
oral vaccine
Bifidobacterium
bacterial vector
anti-PD-1 antibody
bladder cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001200

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http://www.sciencedirect.com/science/article/pii/S2372770521001200

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