A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria.

A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria.

Inflammatory cytokinemia and systemic activation of the microvascular endothelium are central to the pathogenesis of Plasmodium falciparum malaria. Recently, 'parasite-derived' uric acid (UA) was shown to activate human immune cells in vitro, and plasma UA levels were associated with infla...

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Bibliographic Details
Main Authors: Neida K Mita-Mendoza, Diana L van de Hoef, Tatiana M Lopera-Mesa, Saibou Doumbia, Drissa Konate, Mory Doumbouya, Wenjuan Gu, Jennifer M Anderson, Leopoldo Santos-Argumedo, Ana Rodriguez, Michael P Fay, Mahamadou Diakite, Carole A Long, Rick M Fairhurst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3551755?pdf=render

Internet

http://europepmc.org/articles/PMC3551755?pdf=render

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