Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD). However, CDNF and MANF are structurally and functionally clearly distinct from the clas...

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Bibliographic Details
Main Authors: Maria Lindahl, Mart Saarma, Päivi Lindholm
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301711