Toxoplasma gondii inhibits cytochrome c-induced caspase activation in its host cell by interference with holo-apoptosome assembly

Toxoplasma gondii inhibits cytochrome c-induced caspase activation in its host cell by interference with holo-apoptosome assembly

Inhibition of programmed cell death pathways of mammalian cells often facilitates the sustained survival of intracellular microorganisms. The apicomplexan parasite Toxoplasma gondii is a master regulator of host cell apoptotic pathways. Here, we have characterized a novel anti-apoptotic acti...

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Bibliographic Details
Main Authors: Kristin Graumann, Frieder Schaumburg, Thomas F. Reubold, Diana Hippe, Susanne Eschenburg, Carsten G. K. Lüder
Format: Article
Language:English
Published: Shared Science Publishers OG 2015-05-01
Series:Microbial Cell
Subjects:
Toxoplasma gondii
apoptosis
pathogen-host interaction
caspase activation
intrinsic pathway
apoptosome
Apaf-1
Online Access:http://microbialcell.com/researcharticles/toxoplasma-gondii-inhibits-cytochrome-c-induced-caspase-activation-in-its-host-cell-by-interference-with-holo-apoptosome-assembly/

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http://microbialcell.com/researcharticles/toxoplasma-gondii-inhibits-cytochrome-c-induced-caspase-activation-in-its-host-cell-by-interference-with-holo-apoptosome-assembly/

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