Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice

Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice

Abstract Background Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase (PI3K) has been reported to have an important role in neuropathic and i...

Full description

Bibliographic Details
Main Authors: Bing Xu, Cheng Mo, Chengmei Lv, Susu Liu, Jun Li, Jieying Chen, Yanhong Wei, Hongwei An, Li Ma, Xuehai Guan
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Neuroscience
Subjects:
Postoperative pain
Plantar incision
Phosphatidylinositol 3-kinase
Akt
Spinal dorsal horn
Online Access:http://link.springer.com/article/10.1186/s12868-019-0521-9

Internet

http://link.springer.com/article/10.1186/s12868-019-0521-9

Similar Items