Systems biology derived source-sink mechanism of BMP gradient formation

Systems biology derived source-sink mechanism of BMP gradient formation

A morphogen gradient of Bone Morphogenetic Protein (BMP) signaling patterns the dorsoventral embryonic axis of vertebrates and invertebrates. The prevailing view in vertebrates for BMP gradient formation is through a counter-gradient of BMP antagonists, often along with ligand shuttling to generate...

Full description

Bibliographic Details
Main Authors: Joseph Zinski, Ye Bu, Xu Wang, Wei Dou, David Umulis, Mary C Mullins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
BMP signaling
mathematical model-based computational screens
quantitative analysis
BMP diffusion
BMP shuttling
counter-gradient
Online Access:https://elifesciences.org/articles/22199

Internet

https://elifesciences.org/articles/22199

Similar Items