Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner

Pomegranate extract inhibits EMT in clear cell renal cell carcinoma in a NF-κB and JNK dependent manner

Objective: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. One effect of VHL inactivation is hypoxia inducible factor alpha (HIFα)-independent constit...

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Bibliographic Details
Main Authors: Jiabin An, Yanchuan Guo, Ting Wang, Allan J. Pantuck, Matthew B. Rettig
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Asian Journal of Urology
Subjects:
Pomegranate extract
von Hippel-Lindau (VHL) tumor suppressor
Clear cell renal cell carcinoma
c-Jun N-terminal kinase
Epithelial to mesenchymal transition
Nuclear factor kappa B
Online Access:http://www.sciencedirect.com/science/article/pii/S2214388215000326

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http://www.sciencedirect.com/science/article/pii/S2214388215000326

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