Porcine Circovirus (PCV) Genotype 2d-Based Virus-like Particles (VLPs) Induced Broad Cross-Neutralizing Antibodies against Diverse Genotypes and Provided Protection in Dual-Challenge Infection of a PCV2d Virus and a Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

Porcine Circovirus (PCV) Genotype 2d-Based Virus-like Particles (VLPs) Induced Broad Cross-Neutralizing Antibodies against Diverse Genotypes and Provided Protection in Dual-Challenge Infection of a PCV2d Virus and a Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)

As PCV2d infection has been continuously reported in swine farms in which pigs were vaccinated with PCV2a- or 2d-based vaccines, we attempted to develop a novel vaccine using a PCV2d-based capsid to enhance its protective efficacy. In this study, recombinant virus-like particles (VLPs) of rPCV2a, rP...

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Bibliographic Details
Main Authors: Seok-Jin Kang, Sung-Min Bae, Hye-Jeong Lee, Young-Ju Jeong, Min-A Lee, Su-Hwa You, Hyang-Sim Lee, Bang-Hun Hyun, Nakhyung Lee, Sang-Ho Cha
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pathogens
Subjects:
porcine circovirus type 2
recombinant VLP
vaccine
cross-neutralization
Online Access:https://www.mdpi.com/2076-0817/10/9/1145

Internet

https://www.mdpi.com/2076-0817/10/9/1145

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