IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK

IGF1R and Src inhibition induce synergistic cytotoxicity in HNSCC through inhibition of FAK

Abstract Head and neck cancer is the sixth most common cancer worldwide with a 5-year survival of only 65%. Targeting compensatory signaling pathways may improve therapeutic responses and combat resistance. Utilizing reverse phase protein arrays (RPPA) to assess the proteome and explore mechanisms o...

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Bibliographic Details
Main Authors: Christine E. Lehman, Adam Spencer, Sarah Hall, Jeremy J. P. Shaw, Julia Wulfkuhle, Emanuel F. Petricoin, Stefan Bekiranov, Mark J. Jameson, Daniel Gioeli
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90289-1

Internet

https://doi.org/10.1038/s41598-021-90289-1

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