Knockdown of POLQ interferes the development and progression of hepatocellular carcinoma through regulating cell proliferation, apoptosis and migration

Knockdown of POLQ interferes the development and progression of hepatocellular carcinoma through regulating cell proliferation, apoptosis and migration

Abstract Background DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs), whose function in hepatocellular carcinoma has not been investigated. Methods In the present study, both the data col...

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Bibliographic Details
Main Authors: Qi Pan, Lu Wang, Yu Liu, Min Li, Yao Zhang, Wei Peng, Tan Deng, Mei-Ling Peng, Jin-Qiong Jiang, Jiao Tang, Jingjing Wang, Hua-Xin Duan, Sha-Sha Fan
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
POLQ
Cell proliferation
Cell apoptosis
Cell migration
Online Access:https://doi.org/10.1186/s12935-021-02178-2

Internet

https://doi.org/10.1186/s12935-021-02178-2

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