A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

CD81 and its binding partner CD19 are core subunits of the B cell co-receptor complex. While CD19 belongs to the extensively studied Ig superfamily, CD81 belongs to a poorly understood family of four-pass transmembrane proteins called tetraspanins. Tetraspanins play important physiological roles by...

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Bibliographic Details
Main Authors: Katherine J Susa, Tom CM Seegar, Stephen C Blacklow, Andrew C Kruse
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
B cell
tetraspanin
antibody
Online Access:https://elifesciences.org/articles/52337

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