Disruption or reduced expression of the orotidine-5′-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger

Disruption or reduced expression of the orotidine-5′-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger

Abstract Background Aspergillus niger is a filamentous fungus used for the majority of global citric acid production. Recent developments in genome editing now enable biotechnologists to engineer and optimize A. niger. Currently, however, genetic-leads for maximizing citric acid titers in industrial...

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Bibliographic Details
Main Authors: Lihui Zhang, Xiaomei Zheng, Timothy C. Cairns, Zhidan Zhang, Depei Wang, Ping Zheng, Jibin Sun
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Microbial Cell Factories
Subjects:
Aspergillus niger
Citric acid
pyrG
CRISPR/Cas9 system
Tet-on system
Online Access:http://link.springer.com/article/10.1186/s12934-020-01334-z

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http://link.springer.com/article/10.1186/s12934-020-01334-z

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