The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner

The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner

Hepatitis E virus (HEV) is an important human pathogen causing both acute and chronic viral hepatitis E infection. Currently, the mechanisms of HEV replication and pathogenesis remain poorly understood. The innate immune response acts as the first line of defense during viral infection. The retinoic...

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Bibliographic Details
Main Authors: Harini Sooryanarain, Connie L. Heffron, Xiang-Jin Meng
Format: Article
Language:English
Published: American Society for Microbiology 2020-01-01
Series:mBio
Subjects:
hepatitis e virus (hev)
u-rich region rna pamps
retinoic acid-inducible gene i (rig-i)
type i interferon (ifn)
type-iii ifn
Online Access:https://doi.org/10.1128/mBio.03103-19

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