Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282): Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics

Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282): Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics

Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in t...

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Bibliographic Details
Main Authors: Filip Zemek, Jana Karasova Zdarova, Vendula Sepsova, Kamil Kuca
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholinesterase
oximes
human serum albumin
pharmacokinetics
reactivator
antidote
nerve agent
Online Access:http://www.mdpi.com/1422-0067/14/8/16076

Internet

http://www.mdpi.com/1422-0067/14/8/16076

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