Absence of Nucleotide-Oligomerization-Domain-2 Is Associated with Less Distinct Disease in Campylobacter jejuni Infected Secondary Abiotic IL-10 Deficient Mice

Absence of Nucleotide-Oligomerization-Domain-2 Is Associated with Less Distinct Disease in Campylobacter jejuni Infected Secondary Abiotic IL-10 Deficient Mice

Human Campylobacter jejuni-infections are progressively increasing worldwide. Despite their high prevalence and socioeconomic impact the underlying mechanisms of pathogen-host-interactions are only incompletely understood. Given that the innate immune receptor nucleotide-oligomerization-domain-2 (No...

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Bibliographic Details
Main Authors: Markus M. Heimesaat, Ursula Grundmann, Marie E. Alutis, André Fischer, Stefan Bereswill
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Campylobacter jejuni
nucleotide-oligomerization-domain-2 (Nod2)
IL-10−/− mice
secondary abiotic (gnotobiotic) mice
IL-23/IL-22/IL-18 axis
pro-inflammatory immune responses
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00322/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00322/full

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