Exceptionally High Protection of Photocarcinogenesis by Topical Application of (-)-Epi gal locatechin-3-Gal late in Hydrophilic Cream in SKH-1 Hairless Mouse Model: Relationship to Inhibition of UVB-Induced Global DNA Hypomethylation

(-)-Epigallocatechin-3-gal late (EGCG) has been shown to have potent antiphotocarcinogenic activity, but it was required to develop a cream-based formulation for topical application. For topical application, we tested hydrophilic cream as a vehicle for EGCG. Treatment with EGCG (≈ 1 mg/cm2 skin are...

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Bibliographic Details
Main Authors: Anshu Mittal, Chandrika Piyathilake, Yukihiko Hara, Santosh K. Katiyar
Format: Article
Language:English
Published: Elsevier 2003-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800398