Chromatin regulation and gene centrality are essential for controlling fitness pleiotropy in yeast.

There are a wide range of phenotypes that are due to loss-of-function or null mutations. Previously, the functions of gene products that distinguish essential from nonessential genes were characterized. However, the functions of products of non-essential genes that contribute to fitness remain minim...

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Bibliographic Details
Main Authors: Linqi Zhou, Xiaotu Ma, Michelle N Arbeitman, Fengzhu Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2778950?pdf=render