Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension

Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension

Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthetized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously rats (SHR) might contribute to a diminished paracrine ant...

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Bibliographic Details
Main Authors: Beatriz eGálvez-Prieto, Beatriz eSomoza, Marta eGil-Ortega, Concha eF García-Prieto, Ana ede las Heras, María eGonzález, Silvia eArribas, Isabel eAranguez, Juliane eBolbrinker, Reinhold eKreutz, Mariano eRuiz-Gayo, María S Fernández-Alfonso
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Pharmacology
Subjects:
Angiotensin II
Hypertension
Leptin
Nitric Oxide
perivascular adipose tissue
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00103/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00103/full

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