A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells

A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells

Abstract Background Quiescence (G0) is a transient, cell cycle-arrested state. By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause relapse. While G0 cells have been studied at the transcriptome level, how post-transcriptional regulation contributes to their che...

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Main Authors: Sooncheol Lee, Douglas Micalizzi, Samuel S. Truesdell, Syed I. A. Bukhari, Myriam Boukhali, Jennifer Lombardi-Story, Yasutaka Kato, Min-Kyung Choo, Ipsita Dey-Guha, Fei Ji, Benjamin T. Nicholson, David T. Myers, Dongjun Lee, Maria A. Mazzola, Radhika Raheja, Adam Langenbucher, Nicholas J. Haradhvala, Michael S. Lawrence, Roopali Gandhi, Christopher Tiedje, Manuel D. Diaz-Muñoz, David A. Sweetser, Ruslan Sadreyev, David Sykes, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran, Shobha Vasudevan
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Genome Biology
Subjects:
Quiescence
Chemoresistance
Post-transcriptional regulation
AU-rich elements
TTP
Online Access:https://doi.org/10.1186/s13059-020-1936-4

Internet

https://doi.org/10.1186/s13059-020-1936-4

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