TLR-mediated albuminuria needs TNFα-mediated cooperativity between TLRs present in hematopoietic tissues and CD80 present on non-hematopoietic tissues in mice

TLR-mediated albuminuria needs TNFα-mediated cooperativity between TLRs present in hematopoietic tissues and CD80 present on non-hematopoietic tissues in mice

Transient albuminuria induced by pathogen-associated molecular patterns (PAMPs) in mice through engagement of Toll-like receptors (TLRs) is widely studied as a partial model for some forms of human nephrotic syndrome (NS). In addition to TLRs, CD80 has been shown to be essential for PAMP-mediated al...

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Bibliographic Details
Main Authors: Nidhi Jain, Bhavya Khullar, Neelam Oswal, Balaji Banoth, Prashant Joshi, Balachandran Ravindran, Subrat Panda, Soumen Basak, Anna George, Satyajit Rath, Vineeta Bal, Shailaja Sopory
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Disease Models & Mechanisms
Subjects:
CD80
IL-10
Proteinuria
TLR
TNFα
Online Access:http://dmm.biologists.org/content/9/6/707

Internet

http://dmm.biologists.org/content/9/6/707

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