Uremic Toxins Enhance Statin-Induced Cytotoxicity in Differentiated Human Rhabdomyosarcoma Cells

Uremic Toxins Enhance Statin-Induced Cytotoxicity in Differentiated Human Rhabdomyosarcoma Cells

The risk of myopathy and rhabdomyolysis is considerably increased in statin users with end-stage renal failure (ESRF). Uremic toxins, which accumulate in patients with ESRF, exert cytotoxic effects that are mediated by various mechanisms. Therefore, accumulation of uremic toxins might increase stat...

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Bibliographic Details
Main Authors: Hitoshi Uchiyama, Masayuki Tsujimoto, Tadakazu Shinmoto, Hitomi Ogino, Tomoko Oda, Takuya Yoshida, Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Hidehisa Tachiki, Tetsuya Minegaki, Kohshi Nishiguchi
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Toxins
Subjects:
cytotoxicity
statin
uremic toxin
end-stage renal failure
rhabdomyolysis
Online Access:http://www.mdpi.com/2072-6651/6/9/2612

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http://www.mdpi.com/2072-6651/6/9/2612

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