Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

Dextran-Curcumin Nanoparticles as a Methotrexate Delivery Vehicle: A Step Forward in Breast Cancer Combination Therapy

With the aim to effectively deliver methotrexate (MTX) to breast cancer cells, we designed a nanocarrier system (DC) derived from the self-assembly of a dextran-curcumin conjugate prepared via enzyme chemistry with immobilized laccase acting as a solid biocatalyst. Nanoparticles consisted of homogen...

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Bibliographic Details
Main Authors: Manuela Curcio, Giuseppe Cirillo, Paola Tucci, Annafranca Farfalla, Emilia Bevacqua, Orazio Vittorio, Francesca Iemma, Fiore Pasquale Nicoletta
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Pharmaceuticals
Subjects:
polyphenol conjugate
self-assembling nanoparticles
curcumin
breast cancer
synergism
Online Access:https://www.mdpi.com/1424-8247/13/1/2

Internet

https://www.mdpi.com/1424-8247/13/1/2

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