Adapt, recycle and move on: proteostasis and trafficking mechanisms in melanoma

Melanoma has emerged as a paradigm of a highly aggressive and plastic cancer, capable to co-opt the tumour stroma in order to adapt to the hostile microenvironment, suppress immunosurveillance mechanisms and disseminate. In particular, oncogene- and aneuploidy-driven dysregulations of proteostasis i...

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Bibliographic Details
Main Authors: Seyma Demirsoy, Shaun Martin, Hannelore Maes, Patrizia Agostinis
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00240/full