Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals

<i>Background and Objectives</i>: Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of immunomodulatory functions. Individuals with the genetic condition of alpha-1 antitrypsin deficiency (AATD) are at increased risk of early onset emphysematous lung disease....

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Bibliographic Details
Main Authors: Padraig Hawkins, Julian Sya, Nee Kee Hup, Mark P. Murphy, Noel G. McElvaney, Emer P. Reeves
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Medicina
Subjects:
alpha-1 antitrypsin
neutrophils
elastase
voltage-gated proton channel-1
Online Access:https://www.mdpi.com/1648-9144/57/8/814

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https://www.mdpi.com/1648-9144/57/8/814

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