The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.

The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation.

Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone pr...

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Bibliographic Details
Main Authors: Franck Chesnel, Anne Couturier, Adrien Alusse, Jean-Philippe Gagné, Guy G Poirier, Dominique Jean, François-Michel Boisvert, Pauline Hascoet, Luc Paillard, Yannick Arlot-Bonnemains, Xavier Le Goff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009183

Internet

https://doi.org/10.1371/journal.pgen.1009183

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