Abnormal Hypermethylation of CpG Dinucleotides in Promoter Regions of Matrix Metalloproteinases Genes in Breast Cancer and Its Relation to Epigenomic Subtypes and HER2 Overexpression

Abnormal Hypermethylation of CpG Dinucleotides in Promoter Regions of Matrix Metalloproteinases Genes in Breast Cancer and Its Relation to Epigenomic Subtypes and HER2 Overexpression

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) substantially contribute to the regulation of intercellular interactions and thereby play a role in maintaining the tissue structure and function. We examined methylation of a subset of 5’-cytosine-phosphate-guanine-3’ (CpG) dinucl...

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Bibliographic Details
Main Authors: Olga A. Simonova, Ekaterina B. Kuznetsova, Alexander S. Tanas, Viktoria V. Rudenko, Elena V. Poddubskaya, Tatiana V. Kekeeva, Ivan D. Trotsenko, Sergey S. Larin, Sergei I. Kutsev, Dmitry V. Zaletaev, Marina V. Nemtsova, Vladimir V. Strelnikov
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Biomedicines
Subjects:
matrix metalloproteinases
tissue inhibitors of matrix metalloproteinases
DNA methylation
breast cancer
methylation-sensitive restriction enzyme digestion PCR (MSRE-PCR)
genome-wide DNA methylation analysis
Online Access:https://www.mdpi.com/2227-9059/8/5/116

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https://www.mdpi.com/2227-9059/8/5/116

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