Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming

Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated. Human cytomegalovirus (HCMV) infection profoundly affects NK cell compartment, as...

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Bibliographic Details
Main Authors: Cristina Capuano, Simone Battella, Chiara Pighi, Lavinia Franchitti, Ombretta Turriziani, Stefania Morrone, Angela Santoni, Ricciarda Galandrini, Gabriella Palmieri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
memory NK cells
cancer immunotherapy
therapeutic anti-CD20 mAb
CD16
in vitro expansion
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.01031/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.01031/full

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