High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting.

High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting.

Abdurins are a novel antibody-like scaffold derived from the engineering of a single isolated CH2 domain of human IgG. Previous studies established the prolonged serum half-life of Abdurins, the result of a retained FcRn binding motif. Here we present data on the construction of large, diverse, phag...

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Main Authors: Christopher Ullman, Pascale Mathonet, Arkadiusz Oleksy, Agata Diamandakis, Licia Tomei, Anna Demartis, Chiara Nardi, Sonia Sambucini, Antonino Missineo, Karen Alt, Christoph E Hagemeyer, Matt Harris, Amos Hedt, Roland Weis, Kurt R Gehlsen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0135278

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https://doi.org/10.1371/journal.pone.0135278

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