β-adrenergic receptor responsiveness in aging heart and clinical implications

β-adrenergic receptor responsiveness in aging heart and clinical implications

Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called β-adrenergic desensitization). Adren...

Full description

Bibliographic Details
Main Authors: Nicola eFerrara, Klara eKomici, Graziamaria eCorbi, Gennaro ePagano, Giuseppe eFurgi, Carlo eRengo, Grazia Daniela eFemminella, Dario eLeosco, Domenico eBonaduce
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Physiology
Subjects:
Exercise
β-adrenergic receptors
β-adrenoceptor desensitization
β-adrenoceptor down-regulation
G-Protein Coupled Receptor Kinase
Aging heart
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00396/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00396/full

Similar Items