The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

<h4>Objective</h4>The role of the hydroxycarboxylic acid receptor 2 (HCA2) in the retinal damage induced by diabetes has never been explored. In this context, the present study highlights an upregulation of retinal HCA2 receptors in diabetic C57BL6J mice. Moreover, we illustrate that HCA...

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Bibliographic Details
Main Authors: Maria Consiglia Trotta, Rosa Maisto, Francesca Guida, Serena Boccella, Livio Luongo, Cornel Balta, Giovanbattista D'Amico, Hildegard Herman, Anca Hermenean, Claudio Bucolo, Michele D'Amico
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211005

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https://doi.org/10.1371/journal.pone.0211005

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