Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
<p/> <p>Summary</p> <p>Mutations in the adenomatous polyposis coli (<it>APC</it>) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in <it>APC </it>mutant cells is the uncontrolled s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-08-01
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| Series: | Molecular Cancer |
| Online Access: | http://www.molecular-cancer.com/content/10/1/101 |