Function-Oriented Synthesis of Marine Phidianidine Derivatives as Potential PTP1B Inhibitors with Specific Selectivity

Function-Oriented Synthesis of Marine Phidianidine Derivatives as Potential PTP1B Inhibitors with Specific Selectivity

Phidianidines A and B are two novel marine indole alkaloids bearing an uncommon 1,2,4-oxadiazole ring and exhibiting various biological activities. Our previous research showed that the synthesized phidianidine analogs had the potential to inhibit the activity of protein tyrosine phosphatase 1B (PTP...

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Bibliographic Details
Main Authors: Jin Liu, Yu Chen, Jing-Ya Li, Cheng Luo, Jia Li, Kai-Xian Chen, Xu-Wen Li, Yue-Wei Guo
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Marine Drugs
Subjects:
phidianidine
marine natural products
PTP1B inhibitor
specific selectivity
docking analysis
Function Oriented Synthesis
structure-activity relationship
Online Access:http://www.mdpi.com/1660-3397/16/3/97

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http://www.mdpi.com/1660-3397/16/3/97

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