Molecular Features and Metal Ions that Influence 10-23 DNAzyme Activity

Molecular Features and Metal Ions that Influence 10-23 DNAzyme Activity

Deoxyribozymes (DNAzymes) with RNA hydrolysis activity have a tremendous potential as gene suppression agents for therapeutic applications. The most extensively studied representative is the 10-23 DNAzyme consisting of a catalytic loop and two substrate binding arms that can be designed to bind and...

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Bibliographic Details
Main Authors: Hannah Rosenbach, Julian Victor, Manuel Etzkorn, Gerhard Steger, Detlev Riesner, Ingrid Span
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
catalysis
deoxyribozymes (DNAzymes)
gene silencing
metal ion cofactors
RNA hydrolysis
Online Access:https://www.mdpi.com/1420-3049/25/13/3100

Internet

https://www.mdpi.com/1420-3049/25/13/3100

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