Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation

Dendritic cell CNS recruitment correlates with disease severity in EAE via CCL2 chemotaxis at the blood–brain barrier through paracellular transmigration and ERK activation

<p>Abstract</p> <p>Background</p> <p>Transmigration of circulating dendritic cells (DCs) into the central nervous system (CNS) across the blood–brain barrier (BBB) has not thus far been investigated. An increase in immune cell infiltration across the BBB, uncontrolled a...

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Bibliographic Details
Main Authors: Sagar Divya, Lamontagne Anne, Foss Catherine A, Khan Zafar K, Pomper Martin G, Jain Pooja
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Journal of Neuroinflammation
Subjects:
MCP-1
Chemokine ligand 2
Dendritic cell central nervous system trafficking
Blood–brain barrier
Near-infrared fluorescence imaging
Neuroinflammation
Brain microvascular endothelial cells
Online Access:http://www.jneuroinflammation.com/content/9/1/245

Internet

http://www.jneuroinflammation.com/content/9/1/245

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