Dexamethasone and monophosphoryl lipid A-modulated dendritic cells promote antigen-specific tolerogenic properties on naïve and memory CD4+ T cells

Dexamethasone and monophosphoryl lipid A-modulated dendritic cells promote antigen-specific tolerogenic properties on naïve and memory CD4+ T cells

Tolerogenic dendritic cells (DCs) are a promising tool to control T cell-mediated autoimmunity. Here, we evaluate the ability of dexamethasone-modulated and monophosphoryl lipid A-activated DCs (MPLA-tDCs) to exert immunomodulatory effects on naïve and memory CD4+ T cells in an antigen-specific mann...

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Bibliographic Details
Main Authors: Jaxaira Maggi, Katina Schinnerling, Bárbara Pesce, Catharien M Hilkens, Diego Catalán, Juan C Aguillón
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Immunotherapy
tolerance
Monocyte-derived dendritic cells
hyporesponsiveness
Memory CD4+ T cells
naïve CD4+ T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00359/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00359/full

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