Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E

Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E

Increasing resistance of bacteria to antibiotics is a serious global challenge and there is a need to unlock the potential of novel antibacterial targets. One such target is the essential prokaryotic endoribonuclease RNase E. Using a combination of in silico high-throughput screening and in vitro va...

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Bibliographic Details
Main Authors: Charlotte E. Mardle, Layla R. Goddard, Bailei C. Spelman, Helen S. Atkins, Louise E. Butt, Paul A. Cox, Darren M. Gowers, Helen A. Vincent, Anastasia J. Callaghan
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Antibacterial target
Endoribonuclease RNase E
Metabolite-mediated regulation
Small molecule inhibitor
Virtual high-throughput screening (vHTS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820300820

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http://www.sciencedirect.com/science/article/pii/S2405580820300820

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