A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins

A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins

Abstract Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised technologies now allow targeting “undruggable” regions of membrane proteins to modulate protein function in the cell. Despite the adv...

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Bibliographic Details
Main Authors: Rodrigo Aguayo-Ortiz, Jeffery Creech, Eric N. Jiménez-Vázquez, Guadalupe Guerrero-Serna, Nulang Wang, Andre Monteiro da Rocha, Todd J. Herron, L. Michel Espinoza-Fonseca
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96217-7

Internet

https://doi.org/10.1038/s41598-021-96217-7

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