Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrationss⃞

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrationss⃞

The known genetic variants determining plasma HDL cholesterol (HDL-C) levels explain only part of its variation. Three hundred eighty-four single nucleotide polymorphisms (SNPs) across 251 genes based on pathways potentially relevant to HDL-C metabolism were selected and genotyped in 3,575 subjects...

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Bibliographic Details
Main Authors: Yingchang Lu, Martijn E.T. Dollé, Sandra Imholz, Ruben van 't Slot, W.M.Monique Verschuren, Cisca Wijmenga, Edith J.M. Feskens, Jolanda M.A. Boer
Format: Article
Language:English
Published: Elsevier 2008-12-01
Series:Journal of Lipid Research
Subjects:
single nucleotide polymorphism
pathway-driven approach
random coefficient model
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520345892

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http://www.sciencedirect.com/science/article/pii/S0022227520345892

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