A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers

Colorectal cancer patients with the BRAF(p.V600E) mutation have poor prognosis in metastatic setting. Personalized treatment options and companion diagnostics are needed to better treat these patients. Previously, we developed a 58-gene signature to characterize the distinct gene expression pattern...

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Bibliographic Details
Main Authors: Sjors G. J. G. In ’t Veld, Kim N. Duong, Mireille Snel, Anke Witteveen, Inès J. Beumer, Leonie J.M.J. Delahaye, Diederik Wehkamp, René Bernards, Annuska M. Glas, Sun Tian
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:High-Throughput
Subjects:
bioinformatics workflow
personalized medicine
companion diagnostic
BRAF-mutation-like subtype
colorectal cancer
drug repurposing
Online Access:https://www.mdpi.com/2571-5135/6/4/16

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https://www.mdpi.com/2571-5135/6/4/16

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