A Novel Method for Imaging Apoptosis Using a Caspase-1 Near-Infrared Fluorescent Probe

A Novel Method for Imaging Apoptosis Using a Caspase-1 Near-Infrared Fluorescent Probe

Here we describe a novel method for imaging apoptosis in cells using a near-infrared fluorescent (NIRF) probe selective for caspase-1 (interleukin β-converting enzyme, ICE). This biocompatible, optically quenched ICE-NIRF probe incorporates a peptide substrate, which can be selectively cleaved by c...

Full description

Bibliographic Details
Main Authors: Shanta M. Messerli, Shilpa Prabhakar, Yi Tang, Khalid Shah, Maria L. Cortes, Vidya Murthy, Ralph Weissleder, Xandra O. Breakefield, Ching-Hsuan Tung
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Caspase-1
near-infrared fluorescence (NIRF)
apoptosis
brain tumors
HSV
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800551

Internet

http://www.sciencedirect.com/science/article/pii/S1476558604800551

Similar Items