Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes

Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes

Abstract Objective Type 1 diabetes (T1D) is an autoimmune disorder in which autoreactive T cells destroy insulin‐producing β‐cells. Interventions that preserve β‐cell function represent a fundamental therapeutic goal in T1D and biomarkers that predict and monitor β‐cell function, and changes in isle...

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Bibliographic Details
Main Authors: Yassmin Musthaffa, Emma E Hamilton‐Williams, Hendrik J Nel, Anne‐Sophie Bergot, Ahmed M Mehdi, Mark Harris, Ranjeny Thomas
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
antigens
CD4+ T cells
Islet epitopes
proinsulin
proliferation
type 1 diabetes
Online Access:https://doi.org/10.1002/cti2.1315

Internet

https://doi.org/10.1002/cti2.1315

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