Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

Abstract Background Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which is associated with a poor clinical outcome. The pathophysiology of sepsis-as...

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Bibliographic Details
Main Authors: Elisabeth C. van der Slikke, Bastiaan S. Star, Matijs van Meurs, Robert H. Henning, Jill Moser, Hjalmar R. Bouma
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Critical Care
Subjects:
Sepsis
Acute kidney injury
Reactive oxygen species
Mitochondria
Online Access:https://doi.org/10.1186/s13054-020-03424-1

Internet

https://doi.org/10.1186/s13054-020-03424-1

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